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Nerve growth factor receptors are a group of growth factor receptors which specifically bind to neurotrophins. There are two classes of receptors, p75 and the "Trk" family of Tyrosine kinases receptors. * p75 is a low affinity neurotrophin receptor, to which all neurotrophins bind. It is a member of the tumour necrosis super family. In some contexts, the phrase "x" only applies to this receptor. * The Trk family include TrkA, TrkB, and TrkC, and will only bind with specific neurotrophins, but with a much higher affinity. The Trks mediate the functional signals of the neurotrophins. * NGF binds to TrkA, BDNF and NT-4 bind to TrkB and NT-3 binds to TrkC. In addition NT-3 also binds to and activates TrkA and TrkB but it does so less efficiently. * Whilst the Trk receptors have a clearly defined trophic role, p75 receptors activate signalling pathways which can also result in apoptosis. ==TrkA, B, and C receptors== TrkA is a nuclear receptor (meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling). There are other related Trk receptors (TrkB and TrkC), and there are other neurotrophic factors structurally related to NGF (BDNF, NT-3, and NT-4) * TrkA mediates the effects of NGF * TrkB binds and is activated by BDNF, NT-4, and NT-3 * TrkC binds and is activated only by NT-3 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「nerve growth factor receptor」の詳細全文を読む スポンサード リンク
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